Buy DMT Online | What is DMT? | What is Ego Death? | Types of DMT
Buy DMT Online For Depression
Ayahuasca use has been shown to result in reduced ratings of “hopelessness”.
Other studies have shown dramatic improvements in depression scores lasting 21 days (or more) from a single dose of ayahuasca.
Research suggests that DMT may offer significant long-term support for chronic depression.
With that said, research involving ayahuasca instead of pure DMT introduces some questions.
Ayahuasca doesn’t contain just DMT; it’s also abundant in harmaline alkaloids as well which are potent MAO inhibitors and have been shown to have direct antidepressant benefits of their own.
It’s also unclear whether the psychedelic trip itself (along with the introspective insights that come along with it) is responsible for the antidepressant action or if the physiological effects of DMT are responsible.
Buy DMT Online For Addiction
There are no current studies available on the impact of DMT on treating addiction. However, there are a lot of studies highlighting this use for other psychoactive substances like psilocybin and LSD — both of which activate the same receptors as DMT.
Virtually all of the serotonin-dependant psychedelics (LSD, psilocybin, and mescaline) have shown impressive effects on alleviating addictive tendencies.
Buy DMT Online is a particularly interesting option because of its short duration of effects.
It’s much more reasonable to administer DMT that lasts 15 – 30 minutes in an office setting compared to LSD or psilocybin — both of which can last several hours.
How DMT Works
DMT acts like the neurotransmitters glutamate and serotonin.
It interacts with various receptors in the brain that cause a shift in neurochemical balance producing what we experience as an altered perception of reality.
DMT works by interacting with our serotonin receptors specifically through its effects on the 5HT2A receptors — which is the mechanism shared by most psychedelics (LSD, mescaline, MDMA, and psilocybin).
Serotonin is involved with numerous activities in the brain from regulating mood and emotion to regulating the default mode network (DMN).
The subtle differences between different psychedelics come down to the overflow effects these drugs have on other receptors.
Some of these receptors have a stronger impact on visual perception, others with mood or regulation of the DMN.
DMT, in particular, has been shown to interact with the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 receptors .
DMT has also been shown to activate the TAAR1 receptors which are intimately involved with the regulation of neurotransmitters like dopamine in the brain.
The impact of DMT’s ability to activate the TAAR1 receptors is still poorly understood, but it’s believed this interaction plays a key role in the anti-addictive qualities of DMT.
The Sigma-1 Receptors
DMT also activates the sigma-1 receptor — which is a chaperone between the endoplasmic reticulum and mitochondria inside our cells.
The sigma-1 receptor is used to transfer stress from the ER to the nucleus. It’s thought that this interaction of DMT can enhance the production of anti-stress proteins and mitigate oxidative or hypoxic damage.
This is also thought to be the primary mechanism involved with the increased expression of BDNF (brain-derived neurotrophic factor) which is associated with increased neuroplasticity after using DMT.
Other reports suggest the sigma-1 receptor plays may help to improve focus and memory.
Metabolism refers to the enzymatic modification of compounds in the body. Virtually any drug, medication, or supplement is metabolized by the liver, converting it into something that’s easier for the kidneys to remove from the body.
DMT is rapidly metabolized by the body. Peak levels are reached within 15 minutes and are found below detection levels within 1 hour. Only 0.16% of intramuscular DMT injections remain in the blood after 24 hours.
Oral DMT is metabolized even faster. Once this compound is absorbed through the gut, it’s almost completely deactivated by first-pass liver metabolism.
The only way for oral DMT to work is if it’s used in conjunction with a potent MAO inhibitor.